HENU Makes New Progress in the Field of Asymmetric Organic Catalysis

2017-02-28

On February 28th, HENU provincial distinguished Professor Dr. JIANG Zhiyong’s research group published the latest research results online entitled “Catalytic Enantioselective γ-Selective Additions of 2-Allylazaarenes to Activated Ketones” (DOI:10.1002/anie.201700190) in Angewandte Chemie International Edition (the impact factor of 11.709), the international top journals in the field of chemistry. 

How to construct chiral nitrogen-containing aromatic heterocycles by asymmetric catalysis has attracted more and more attention from chemists. Dr. JIANG Zhiyong’s research group used self designed and developed two peptides derived urea-amide-tertiary amine as Bronsted base catalyst (Chem. Sci. 2016, 7, 6060 and 6067), and deuterogenic urea-quaternary ammonium salt phase transfer catalyst (J. Org. Chem. 2015, 80, 7770−7778) based on amino acid derivative (thio) urea and tertiary amine (Angew. Chem. Int. Ed. 2012, 51, 10069–10073; Angew. Chem. Int. Ed. 2013, 52, 6666–6670; Org. Lett. 2013, 15, 2358−2361; Angew. Chem. Int. Ed. 2016, 55, 1299−1303), achieving γ-selective allylation of 2-Allylazaarenes and isatins and trifluoromethyl ketones, highly stereoselectivly synthesized series of tertiary alcohol δ-position important chiral nitrogen-containing aromatic heterocycles.

The first author of the paper is BAI Xiangbin, a graduate student of the 2014 from the Key Laboratory of Natural Medicine and Immunology, and Dr. JIANG Zhiyong is the only correspondence author.