HENU Makes New Progress in the Field of Asymmetric Organic Catalysis
On February 28th, HENU provincial distinguished Professor Dr. JIANG Zhiyong’s research group published the latest research results online entitled “Catalytic Enantioselective γ-Selective Additions of 2-Allylazaarenes to Activated Ketones” (DOI:10.1002/anie.201700190) in Angewandte Chemie International Edition (the impact factor of 11.709), the international top journals in the field of chemistry.
How to construct chiral nitrogen-containing aromatic heterocycles by asymmetric catalysis has attracted more and more attention from chemists. Dr. JIANG Zhiyong’s research group used self designed and developed two peptides derived urea-amide-tertiary amine as Bronsted base catalyst (Chem. Sci. 2016, 7, 6060 and 6067), and deuterogenic urea-quaternary ammonium salt phase transfer catalyst (J. Org. Chem. 2015, 80, 7770−7778) based on amino acid derivative (thio) urea and tertiary amine (Angew. Chem. Int. Ed. 2012, 51, 10069–10073; Angew. Chem. Int. Ed. 2013, 52, 6666–6670; Org. Lett. 2013, 15, 2358−2361; Angew. Chem. Int. Ed. 2016, 55, 1299−1303), achieving γ-selective allylation of 2-Allylazaarenes and isatins and trifluoromethyl ketones, highly stereoselectivly synthesized series of tertiary alcohol δ-position important chiral nitrogen-containing aromatic heterocycles.
The first author of the paper is BAI Xiangbin, a graduate student of the 2014 from the Key Laboratory of Natural Medicine and Immunology, and Dr. JIANG Zhiyong is the only correspondence author.